Interim Analyses & Alpha Spending: Designing Early Looks that Preserve Error Control and Credibility
Interim Analyses & Alpha Spending: Designing Early Looks that Preserve Error Control and Credibility Interim Analyses and Alpha Spending: Early Decisions with Rigor and Regulatory Confidence Early Looks with Discipline: Objectives, Risks, and the Regulatory Lens Interim analyses allow data-driven decisions before the scheduled end of a clinical trial. Done well, they can accelerate patient…